UG 100 - Now even more
powerful with Solaris

Unique flow-based chemistry

Ultima's unique single base flow chemistry was built for speed, efficiency, and accuracy where you need it most. Our chemistry inherently provides advantages for calling SNVs by asking how many nucleotides are added, but the base identity is never in question. Incorporating one type of nucleotide per flow enables an extremely low base substitution error rate.

ppmSeq for even more accurate SNV calling

ppmSeq™, or paired plus minus sequencing, is Ultima's ground-breaking method to achieve accuracy of one part per million or better for calling single nucleotide variants (SNVs). ppmSeq combines the strong base calling performance of Ultima's flow chemistry with automated emulsion-based clonal amplification to sequence, identify and remove disagreement between both strands of a captured DNA molecule caused by sample error. Achieve extreme SNV quality without needing to over sequence.

SNVQ is the single nucleotide variant quality (SNVQ) score, which is different from a standard base quality score. The SNVQ score represents the error probability of the specific base substitution (e.g., A>G) rather than the aggregate error probability of any substitution (e.g., A>C/G/T).

Accurate homopolymer measurement

Ultima's UG 100™ solves the homopolymer challenges that limited previous flow-based chemistries. By using steady state imaging and modern machine learning techniques, Ultima's chemistry performs well in measuring homopolymers so that you can now benefit from an extreme level of SNV accuracy with a high indel quality even with non-terminating chemistry.

Indel calling accuracy F1 per homopolymer indel length.