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Germline
The $80 genome,
do more for less
The Ultima Advantage
The UG 100 Solaris Free workflow delivers even more affordable whole genome sequencing, enabling larger-scale.
Learn about UG 100| Reads per wafer | Price per whole genome* | Price per Gb | Price per million reads | |
|---|---|---|---|---|
| UG 100 with Solaris™ | 10 - 12 B | $80 / genome | $0.80 / Gb | $0.24 per million reads |
| UG 100™ (2024) | 6 - 8 B | $100 / genome | $1 / Gb | $0.30 per million reads |
*Per genome cost based on list price over 4 wafers.
Built-in 24/7 automation maximizes sequencing throughput while minimizing operator touchpoints. Hot swap consumables and samples to leverage the UG 100™ for continuous sequencing operation to meet your greatest production scale needs.
Learn more about the UG 100™| Reads PF per wafer | Wafer throughput per week* | Wafer throughput per year | |
|---|---|---|---|
| UG 100 with Solaris™ | 10 - 12 B | Up to 24 wafers | More than 30,000 whole genomes |
| UG 100™ (2024) | 6 - 8 B | Up to 20 wafers | Up to 20,000 whole genomes |
The UG 100™ Sequencing Platform performs on-board secondary analysis and is compatible with leading cloud and on-prem solutions. We partnered with AWS to offer our Genomics DeepVariant Ready2Run workflow on AWS HealthOmics at a $2 price per run in AWS US Regions (N. Virginia and Oregon). For pricing in other AWS regions please visit, AWS HealthOmics pricing.
Discover our AWS Ready2Run Solution
The UG 100™ sequencer solves the homopolymer challenges that limited previous flow-based chemistries to provide high quality data across the whole genome. Using steady state imaging and modern machine learning techniques, you can now benefit from an extreme level of SNV accuracy with a high indel quality, even with non-terminating chemistry.
| INDEL | SNP | ||||||
|---|---|---|---|---|---|---|---|
| # of reads | Precision | Recall | F1 | Precision | Recall | F1 | |
| HG001 | 500,626,685 | 99.76% | 99.43% | 99.59% | 99.95% | 99.80% | 99.87% |
| HG002 | 527,092,708 | 99.84% | 99.56% | 99.70% | 99.99% | 99.77% | 99.88% |
| HG003 | 505,472,435 | 99.80% | 99.47% | 99.64% | 99.96% | 99.74% | 99.85% |
| HG004 | 509,418,653 | 99.82% | 99.53% | 99.67% | 99.98% | 99.79% | 99.89% |
| HG005 | 504,323,942 | 99.82% | 99.59% | 99.71% | 99.97% | 99.81% | 99.89% |
| Average | 509,386,885 | 99.81% | 99.51% | 99.66% | 99.97% | 99.78% | 99.87% |
Variant calling performance was assessed in comparison to reference truth sets within the UG high-confidence region (HCR), which covers >99% of the GIAB v4.2.1 HCR and excludes genomic areas where UG performance is consistently of lower confidence, such as homopolymer regions of length >12 bp and limited regions of low complexity (see Github here).
Genomics at scale with
UG 100 Solaris™ Free
The UG 100 Solaris™ Free workflow offers PCR-free native library prep compatible with leading library prep kits and able to accommodate a range of sample types and input amounts.
Explore Solaris library prepHighlights
| PCR-Free Whole Genome Sequencing | |
|---|---|
| Adapter names | xGen™ PCR-Free Adapters for Ultima Genomics® |
| Purchase from | IDT |
| Sample indexing | 192 sample indices |
| DNA type | Genomic DNA (gDNA) |
| DNA input range | 100 - 500 ng* |
*DNA input amounts verified by Ultima Genomics.
An ecosystem of partner
solutions on the UG 100
Order xGen™ for Ultima Genomics®
Access our Github repo for documentation to run our fast and cost-effective UG-adapted DV variant caller on AWS Healthomics.
Learn how Fabric Genomics optimized their tertiary analysis pipeline for turnkey interpretation of Ultima Genomic's data.
Learn how Ultima's flow chemistry is uniquely sensitive to calling SNVs and about our integrated on-board analysis pipelines.
Community testimonial
Ultima Genomics’ architecture will revolutionize sequencing and take what we can do to a whole new level. The ability to sequence many thousands of genomes and epigenomes will transform diagnostics and disease risk prediction.
Mike Snyder, PhD | Director, Center for Genomics and Personalized MedicineStanford University, August 2022
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Certified Service Providers
Access cost-effective and scalable sequencing through our growing network of global service providers vetted for technical expertise and adherence to best practices. Submit samples and start generating data on the UG 100 Sequencer now.
Sequence with a CSP todayTechnology Access Program
Our Technology Access Program offers accessible entry to the UG 100™ through our in-house applications lab. Sequence on our high-capacity fleet of UG 100 Sequencers and receive support at every step, from consultation through data analysis.
Discover our TAP offeringsBring UG 100 into your lab
Interested in exploring how your lab can benefit from high-throughput, cost-effective sequencing? Learn how our novel use of open wafers and built-in automation is continuously driving the cost of sequencing down to accelerate omics at scale.
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